Stem cell research and its usage as a intervention has been the hottest subject for arguments from the last few old ages. Stem cells are a particular sort of cells in the organic structure which have the possible to renew damaged tissue in the organic structure by developing into other types of cells like liver cells, bosom cells, etc. Stem cells usually function in the organic structure to keep optimum wellness by replacing dysfunctional cells. There are three different types of root cells depending on their beginning which are embryologic, grownup and fetal root cells. These cells are engineered which so leads to the intervention of assorted unwellness like Alzheimer ‘s disease, Schizophrenia, Parkinson ‘s disease, Autism, Heart disease, etc. Even though root cell therapies challenge to bring around many unwellnesss it carries a batch of hazard related to the therapies which might turn out to be lethal for the patient. For e.g. as per a new research, root cell therapy was used on bosom disease patients and later it was observed that it resulted in doing the coronary arterias narrower.
PROBLEMS RELATED TO STEM CELL THERAPIES:
Stem cell therapies have given people enduring from earlier incurable disease a new hope. The Dopastat bring forthing nerve cells in human brains the decease of which in Parkinson ‘s disease causes palsy can be replaced by root cell therapy ( Zubin et al. , 2007 ) . Bone marrow graft ( BMT ) a popular clinical application is used to reconstruct the blood cells of different types after chemotherapy to extinguish the endogenous malignant neoplastic disease cells. Skin root cells called the keratinocytes taken from the hair follicle after tweaking the hair. These cells are so civilization to acquire an cuticular bed similar to that of the patient and so used for autologous grafting which wipes out the hazard of rejection ( Murielle Mimeault and Surinder K. Batra, 2010 ) . In diabetes it has been seen that the Beta cell mass and its maps are reduced. To bring around this, in-vitro or in-vivo differentiated regeneration of insulin bring forthing cells are transplanted which is the most appropriate attack for beta cell regenerative therapy ( Jun HS, 2010 ) .
PROBLEMS RELATED TO STEM CELL THERAPIES:
In root cell grafts used for root cell therapy, safety of the patient is the most of import thing to be kept in head. Stem cell grafts carry a possible side consequence and complication whether it is an autologous transplant or an allogenic. Thus the research workers face many challenges when it comes to stem cell grafts and these should be overcome before this method is used to get the better of assorted diseases.
Immunological rejection is a really common job in root cell grafts. In this the immune system of the patient ‘s organic structure recognizes the transplanted cells as foreign and so wages an onslaught on them. This is called as the Graft Versus Host Disease ( GVHD ) . Here the giver ‘s immune cells or the T cells are non recognized by the HLA antigens due to which it rejects it. In some instances the transplant fails to turn after the graft therefore ensuing in a transplant failure. This leads to the bone marrow failure which so causes under production of ruddy blood cell, white blood cells and thrombocytes ensuing in anemia, infection, shed blooding etc. A status called entire transplant failure is a rare status but is life endangering ( Techung Lee, 2010 ) .
After chemotherapy and the root cell transplant the white blood cell count goes down and therefore the immune system becomes weak. This makes the patient susceptible to infections even from bacteriums present in the normal organic structure vegetations. Even the ruddy blood cell count goes down and along with it the hemoglobin degree which makes the patient anaemic and the patient becomes weak and experiences weariness.
Another job seen after organ transplant is the Veno-Occlusive Disease occurs due to damage caused to the liver as a consequence of high degrees of chemotherapy. It by and large happens to patients who have had old liver harm or hepatitis or have been through chemotherapy intervention before. It is largely seeable within first two hebdomads of the graft and by and large causes icterus, liver swelling, weight addition ( Women ‘s Health ) .
Some serious long term side effects are besides seen after the organ transplant. Infertility is one of them. Entire asepsis is observed in male every bit good as females merely if entire organic structure irradiation is done in some instances the younger adult females are seen to retrieve ovulatory and catamenial rhythm after the graft but hormonal replacing therapy is necessary. Cataracts in the oculus are besides seen in patients who have undergone a entire organic structure irradiation. These occur chiefly in patients taking steroid doses and starts developing largely between 18 and 24 months after the graft ( Women ‘s Health ) .
It increases the opportunity of development of secondary malignant neoplastic disease after the chemotherapy intervention but largely it is seen in chest malignant neoplastic disease that the opportunities of developing secondary malignant neoplastic disease after the intervention is less than 2 % . The opportunities of developing a secondary malignant neoplastic disease in lymphoma patients are about 8 to 10 % after they have undergone chemotherapy and an autologous root cell graft ( Explore root cells ) .
Even though the root cell therapies have brought immense alleviation to many people enduring from disease which were thought to be incurable, it besides brings along with it many other hazards which might or might non demo up in the patient. These side effects are largely those like the 1s that are normally seen after chemotherapy. These are edge to go on due to the usage of big and strong doses of drugs towards the intervention and disposal of the root cell therapy. The symptoms vary from individual to individual and one patient might demo all the side effects while the other might non demo any at all. So to develop the root cell therapy as a major technique for intervention of assorted diseases the research workers have to first get by up with these side effects that tag along with the therapy and come up with a strong defence for each to do this successful and therefore used by all.